Government Agents: AI Agents Meet Tough Regulations — Mark Myshatyn, Los Alamos National Lab
Dec 6, 2025 · 16:31
Mark Myshatyn, Enterprise AI Architect at Los Alamos National Laboratory, describes how the lab is building AI agents for scientific research under strict federal regulations. He showcases an agent that reads fusion capsule papers, designs a hypothesis, and runs simulations on high-performance computing assets, integrating 60+ years of physics models. He stresses the need for explainability, isolation, and governance in government AI tools, citing OMB memoranda M2521 and M2522 mandating faster AI adoption with real-world impact. The lab partners with frontier labs like OpenAI for chem-bio safety work, and with NVIDIA and HPE for the Venado supercomputer. He urges startups to build for DoD IL5 environments and continuous compliance to succeed in federal procurement, noting Los Alamos holds petabytes of never-internet data and specializes in sensors like the ChemCam on Mars.
